Comprehending fibroblast growth factor receptor like 1: Oncogene or tumor suppressor?

Comprehending fibroblast growth factor receptor like 1: Oncogene or tumor suppressor?

Blog Article

Fibroblast Growth Factor Receptor Like 1 (FGFRL1) signaling has crucial role in a multitude of processes during genetic diseases, embryonic development and various types of cancer.Due to its partial structural similarity with its classical Fibroblast Growth Factor Receptor [FGFR] counterparts and lack of tyrosine kinase domain, FGFRL1 was thought to work as a decoy receptor in FGF/FGFR signaling.Later on, growing Mounting number evidences showed that expression of FGFRL1 affects major pathways like ERK1/2, Akt and others, which are dysfunctional in a wide range of human cancers.In this review, we provide an overview of the current understanding of FGFRL1 and its Astaxanthin roles in cell differentiation, adhesion and proliferation pathways.Overexpression of FGFRL1 might lead to tumor progression and invasion.

In this context, inhibitors for FGFRL1 might have therapeutic benefits in human cancer prognosis.